Synthetic Combinatorial Library (SCL)

Synthetic Combinatorial Libraries (SCLs) are systematically designed using structure–activity relationship (SAR) insights to maximize both chemical diversity and biological relevance. By strategically varying substituents on well-defined molecular scaffolds, we generate diverse compound collections that can be rapidly screened with mass spectrometry.

While DNA-encoded libraries (DELs) also rely on split–pool synthesis, SCLs remove the need for DNA tags by leveraging spectral deconvolution within the Spectra Decoding Platform (SDP). This integration enables efficient mapping of scaffold–target interactions and expands access to novel chemical space beyond the reach of DELs and conventional structure based drug discovery (SBDD) methods.

SCLs not only accelerate hit identification but also support lead optimization to provide a direct path from early screening to validated drug candidates.

Key Features:

• Accelerates Hit-to-Lead Development

Rapidly refines promising scaffolds by systematically varying functional groups in combinatorial libraries.

• Employs Split–Pool Synthesis Without DNA Tags

Uses combinatorial split–pool synthesis while eliminating DNA tags through SDP-based spectral deconvolution.

• Applies SAR-Guided Design

Incorporates structure–activity relationship insights to enhance biological relevance and chemical diversity.

• Expands Chemical Space Access

Provides scaffold–target interactions and novel chemotypes beyond the reach of DELs and traditional synthesis.

• Integrates with Mass Spectrometry

Directly couples with high-resolution mass spectrometry for high-throughput screening.

• Improves Lead Optimization

Streamlines the hit-to-lead transition with libraries designed for favorable ADME/DMPK properties.