Bioanalytical Mass Spectrometry Core

(In Progress)

At Linker Sciences, our primary focus is on conducting rigorous experiments using high-resolution mass spectrometry (HRMS) instruments. We aim to configure these instruments to allow direct and precise measurement of receptor–drug interactions to enable us to confirm biological relevance early in the drug discovery process. To support this, we are outfitting our lab with ultra-high-resolution mass spectrometers, advanced liquid chromatography systems, automated sample preparation platforms, and a comprehensive suite of chromatography and extraction tools. This advanced infrastructure enables us to perform reproducible, high-throughput validation studies that are essential for identifying clinically meaningful drug candidates.

High-Resolution Mass Spectrometry

We plan to equip our lab with high-resolution mass spectrometers capable of handling complex data acquisition in challenging biological matrices. These instruments will serve as the core engines of our discovery platform, enabling precise measurement of receptor–ligand interactions. As we expand our pipeline and scale operations, we intend to increase the number of HRMS instruments to support growing experimental demands.

Separation Suite

Working with complex biological matrices requires more than just detection—it demands precise separation. While our HRMS instruments can identify trace-level components, isolating candidate compounds with unknown drug-like structures requires a powerful suite of separation technologies. To meet this need, we are building an advanced separation suite that includes preparative and analytical chromatography systems, solid-phase extraction platforms, and orthogonal fractionation tools. This setup is essential for purifying active compounds to enable detailed physiochemical characterization and functional validation in downstream experiments.

Extraction suite

We are outfitting our lab with advanced extraction tools designed for efficient recovery of bioactive compounds from complex natural sources. This includes an accelerated solvent extraction system for high-throughput processing and rotary evaporators for precise solvent removal under controlled conditions. These systems minimize contamination, preserve compound integrity, and ensure consistent yields. By standardizing our extraction workflows, we lay a critical foundation for reliable downstream separation, analysis, and validation of therapeutic candidates.

Automated Sample Preparation

We employ automated sample preparation systems to standardize and accelerate processing across large compound libraries and complex biological samples. These platforms perform critical steps with high precision and minimal variability. By eliminating manual inconsistencies, we ensure reproducibility, reduce contamination risk, and maintain the integrity of samples throughout analytical and bioassay workflows. This automation is essential for high-throughput screening and robust data generation in modern drug discovery.

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