Natural Product Library (NPL)

As an American-owned company, we systematically source and characterize unique natural products with high drug-likeness potential from North America’s underexplored ecosystems. This untapped region holds massive chemical biodiversity with the potential to unlock new therapeutic opportunities.

Using advanced high-resolution mass spectrometry combined with AI-driven analytics, we catalogue a chemically rich and diverse Natural Product Library spanning small molecules and short peptides optimized for modern drug discovery applications.

Our Natural Product Libraries (NPLs) are curated into specialized kits, organized by molecular class and physicochemical profile, to enable rapid and systematic screening against a broad range of biological receptors.

Key Features:

Accelerates Drug Discovery

Optimizes early-stage pipelines by enabling hit identification and scaffold prioritization within libraries enriched for favorable ADME/DMPK properties to facilitate efficient lead optimization.

Explores Biodiversity

Systematically investigates North America’s underexplored ecosystems as a source of novel drug-like compounds.

Integrates Advanced Technologies

Couples high-resolution mass spectrometry with AI-driven analytics for precise identification and characterization.

Expands Chemical Space

Provides comprehensive coverage of small molecules and short peptides with diverse structural and physicochemical properties.

Delivers Modular Library Kits

Curates compounds into specialized kits organized by molecular class and property space for targeted screening.

Supports Screening Readiness

Formats libraries for rapid evaluation across broad receptor classes and adaptable assay platforms.

Primary Sources of Novel Natural Drug-Like Compounds

North America Lakes

Xinghamide A, a novel cyclic nonapeptide from Streptomyces xinghaiensis originally isolated from marine sediments in South Korea, highlights the untapped therapeutic potential of Streptomyces species (Link). Related strains in Utah’s Great Salt Lake (Link) suggest that North America’s inland lakes, including the Great Lakes, potentially host similarly rich and chemically diverse microbial ecosystems.

At Linker Sciences, we are systematically bioprospecting North America ecosystems to isolate, characterize, and catalog novel microorganisms. This strategy enables the discovery of bioactive molecules with strong intellectual property potential which are incorporated into our Natural Product Library (NPL) kits.

Medicinal Mushrooms Native to North America

Indigenous people have long used North American fungi for immune support, wound care, and overall wellness. While most medicinal mushroom research focuses on Asian species like Ganoderma lucidum (Reishi) and Lentinula edodes (Shiitake), North America’s diverse mycobiota remains largely untapped (Link). Species such as Fomitopsis betulina (Birch Polypore), Hericium coralloides (Comb Tooth), and Inonotus obliquus (Chaga) show promising antimicrobial (Link), neuroprotective (Link), and anticancer activity (Link) but remain under-characterized at the molecular level.

At Linker Sciences, we integrate ethnobotanical knowledge with untargeted mass spectrometry, metabolomics, and AI-guided analytics to systematically screen these mushrooms, translating traditional use into validated, patentable therapeutics.

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