Sr. Scientist — Synthetic Biology

Job Title: Senior Scientist – Synthetic Biology
Job Type: Contract/Full-time

Position Summary:
We are seeking a Medicinal Chemist with expertise in synthesizing combinatorial libraries and operating modern synthesis instrumentation. The ideal candidate will have hands-on experience designing and executing parallel reactions, optimizing synthetic routes, and contributing to hit-to-lead efforts. This is a lab-based role within a fast-moving startup focused on accelerating small molecule drug discovery through automation and scalable synthesis.

Key Responsibilities:

• Design, synthesize, and purify small molecule libraries using parallel synthesis strategies

• Operate and maintain synthesis instrumentation (e.g., automated parallel synthesizers, microwave reactors, liquid handlers)

• Troubleshoot and optimize reaction conditions for scalability and reproducibility

• Work with analytical teams to confirm purity and structure (LC-MS, NMR, HPLC)

• Collaborate with computational and screening scientists to prioritize library design

• Maintain detailed experimental records and contribute to internal protocols and workflows

• Present results in internal meetings and contribute to decision-making on compound prioritization
  
  

Qualifications:

• Ph.D. in Organic Chemistry, Medicinal Chemistry, or a related field with 2+ years of relevant industry experience

• Strong background in modern synthetic organic chemistry and parallel synthesis

• Experience in building focused and diverse combinatorial libraries

• Proficient in operating synthesis instrumentation and handling multistep reactions

• Familiar with purification methods and structural characterization techniques

• Ability to manage multiple projects in a fast-paced research environment
  
  

Preferred:

• Exposure to automated synthesis platforms and miniaturized reaction formats

• Familiarity with structure–activity relationship (SAR) principles and hit-to-lead optimization

• Comfortable working in early-stage drug discovery and startup environments
  
  

Growth Opportunity:
This is a foundational hire. The successful candidate will help shape the company’s scientific direction and grow into a leadership role as the organization expands.

To Apply:
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